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Immunological and Haematological Sciences and Reumatology

Offered by

Sapienza Università di Roma

Fields of Study

Medical, Pharmaceutical and Veterinary Medical Sciences

Working Languages

Italian, English

Programme

Immunological and Haematological Sciences and Reumatology

Research Areas

The PhD course on Immunological, Hematological and Rheumatological Sciences is aimed at strengthening the connection between areas of basic and clinical research in the fields of immunology, immunopathology, clinical immunology, hematology, and rheumatology, and promoting the transfer of knowledges derived from bench to clinical applications by the usage of integrated experimental approaches. The PhD course will include the following curricula:

The Immunology and Immunopathology curriculum will be focused on a better understanding of the functions of the different immune cells, on different signals and mediators underlying the immune response, on molecular mechanisms regulating the activation and the development of the immune response, as well as on the role of histocompatibility antigens in control of immune response. These topics will be analyzed through the study of mediators, receptors, and molecular pathways. In addition, the interactions between the immune system of the host organism and the mechanims of pathogenesis of infectious agents such as viruses, bacteria and fungi will be also taken into accout. It will also address the study of the major mechanisms of pathogenesis underlying autoimmune and lymphoproliferative diseases, immunodeficiencies and allergic reactions. Particular attention will be devoted to the study of host-tumor interactions based on an analysis of the molecular and genetic aspects that regulate this interaction. These research activities will be carried out within research projects in collaboration with national and international scientific institutions.

The Clinical Immunology curriculum intends to train students capable of developing their own research line in various fields of Clinical Immunology, taking into account both pathogenic and clinical/therapeutic aspects. Knowledge on interactions between immune system and infectious agents will be acquired, mainly using primary immunodeficiency diseases as a model. To this end, the study of the genetic and immunological characteristics of primary immunodeficiencies, with particular emphasis on the common variable immunodeficiency, will be associated with the analysis of susceptibility to infection by different microorganisms. Doctoral students will have the opportunity to study the mechanisms by which some viruses, such as HCV and HIV, lead to an immune response dysregulation, inducing lymphoproliferative disorders or suppression of immune responses. With regard to lymphoproliferative disorders, particular attentino will be given to the study of the pathogenic mechanisms and molecular characteristics of non-Hodgkin's lymphoma secondary to HCV infection and the Sezary syndrome. Finally, the role of B cells in the pathogenesis of autoimmune diseases will be also addressed. Students will be able to acquire scientific knowledges and innovative technologies, developing their own original and independent research activity. The research will be performed in part on a basis of cooperation with Italian and foreign research centers.

The Hematology curriculum will be focused on the study of the different biological mechanisms underlying the pathogenesis of hematological diseases of children and adults. Essential to the student’s learning process will be the acquisition of a theoretical basis for the implementation of laboratory methods necessary for a modern characterization of the different hematological diseases. This is a prerequisite for the accomplishment of biological and clinical research programs in various fields of neoplastic and non-neoplastic hematology. The educational purpose to be achieved will be primarily directed towards a better characterization of both acute and chronic hematological malignancies (leukemias, lymphomas, myelomas), and to a more precise diagnosis through the combined use of different and complementary technologies. New technologies open up additional scenarios of translational research as synthesis between basic research and clinical applications. In this context, particular emphasis will be given to the design and implementation of innovative therapeutical protocols for patients with neoplastic and non-neoplastic hematological diseases. The primary goal of the PhD is to develop more advanced scientific projects in translational research aimed at optimal and progressively more personalized management of patients with hematological disorders, including the progressive use of targeted therapies. The laboratories of phenotypic and functional Immunology, conventional and molecular cytogenetics, molecular biology, gene sequencing, cell culture, cell kinetics and apoptosis, signal transduction, genomics, hemostasis and thrombosis, etc. and their tight integration with care facilities ensure skills necessary to accomplish the objectives. Much research activities will be carried out in collaboration with various national and international research centers.

The Curriculum of Clinical and Experimental Rheumatology will be focused on the study of the different aspects of the molecular and cellular mechanisms underlying the pathogenesis of both systemic and local (joint, muscle, skin, etc.) rheumatic diseases. Essential in the education process of the student will be the acquisition of the theoretical basis for the implementation of laboratory methods needed to carry out research programs aimed at studying patients peripheral blood cells, serum, synovial membrane, synovial fluid, the cartilage and subchondral bone. The student will also acquire knowledge in the relationship between the mechanisms of pathogenesis and the clinical signs of rheumatic diseases, linking the results of basic research with major clinical features of these diseases also through the use of appropriate instrumental methods (X-ray techniques, MRI, ultrasound, capillaroscopy, etc..) employed in Rheumatology. The therapeutic application of recent acquisitions on the pathogenesis of rheumatic diseases will also be of primary importance. Finally, the recent introduction into clinical practice of innovative drugs able to act selectively on different molecular targets has opened new frontiers in the field of pharmacology applied to rheumatology with many pharmacogenetic and pharmacoeconomic implications. These issues represent a further opportunity for integrating basic and translational research.

PhD Full

Starting date:Nov 01, 2017
Duration:36 months

PhD Sandwich

Starting date: from Nov 01, 2017
Duration: from 3 to 12 months

Postdoc

Starting date: from Nov 01, 2017
Duration: from 3 to 12 months

Master research

Starting date: from Nov 01, 2017
Duration: from 3 to 6 months

Contacts

Academic contact

Martina Vizzani

Institutional contact

Martina Vizzani